The hotel’s signature restaurant Anima is courtyard dining at its finest, with over 400 plants leaning across a convivial setting that makes an excellent backdrop for enjoying a menu of Roman- and Neapolitan-inspired dishes by chef Antonio Gentile. (If you prefer to dine indoors, there’s also the Yves Klein Blue Room with velvet furniture, French windows, and commissioned paintings by Johina Garcia-Concheso.) And no stay here is complete without a foray to the rooftop for a cocktail or dip in the travertine plunge pool.

• Amenities: Restaurant, two bars, rooftop, pool, spa treatment room
• Address: Salita di S. Nicola da Tolentino, 14, 00187

Photo: Courtesy of The Hoxton, Rome

Hoxton properties have always been a compelling choice for stylish accommodations that are gentler on the wallet. Their Rome outpost is in the upscale Parioli neighborhood and has 192 bedrooms, a cocktail bar, and a restaurant serving lunch and dinner. If you’ve stayed in a Hoxton before, you’ve likely already come to expect polished design touches; at this particular outpost, the details take the form of Murano glass chandeliers, vintage furnishings, and parquet floors galore.

The hotel sits within a 1970s modernist space, and its neighbors include romantic villas and modern art galleries alike. Vogue’s associate shopping director Talia Abbas points to the hotel’s atmosphere as a key selling point: “It’s delightfully airy and there’s quite a bit of greenery around,” she says. “There’s also a lovely grocer across the street if you need to grab provisions before heading out for a day of sightseeing, and there’s even a market that takes place on one of the side streets during the weekend. It was the perfect 24-hour rest stop from my mom’s hometown in Calabria before flying back to New York City.”

• Amenities: Restaurant, bar, complimentary bikes, Hox Shop, laundry service
• Address: Largo Benedetto Marcello, 220, 00198